NRC — Zebrafish research facility
At a glance
- No Condition
- Open Date : November 14, 2019
- All industries
- National Research Council Canada
- Government of Canada
Overview
Eligibility criteria
Who is eligible
Companies in the biotechnology, pharmaceutical, natural health product, and human health therapeutics industries can apply for this grant to utilize the zebrafish research facility for developing and validating a range of in vivo assays, methods, and disease models for industry-specific applications.
Eligible expenses
There are eligible expenses for this grant:
- Preclinical toxicity profiling
- Identification of mechanism of action
- Omics techniques
- Pharmacological testing
- Microscopy
- High-throughput behavioural tracking
- Intravenous and intracerebroventricular administration
Eligible projects & activities
As the grant context provided focuses on the zebrafish research facility and its capabilities, there are no specific projects or activities mentioned as eligible for the grant.
Evaluation & selection criteria
There are evaluation and selection criteria for this grant. The evaluation and selection criteria include:
- Scientific merit and significance of the proposed research
- Alignment with industry-specific applications
- Feasibility and appropriateness of the experimental approach
- Potential impact on toxicological and pharmacological studies
- Potential for collaboration and knowledge exchange
How to apply
To apply for this grant, you can contact the following individuals for business or technical inquiries: Business inquiries: James De Pater Telephone: 613-614-9547 Email: James.DePater@nrc-cnrc.gc.ca Technical inquiries: Lee Ellis, Research Officer Telephone: 902-426-2239 Email: Lee.Ellis@nrc-cnrc.gc.ca You can reach out to them for more information on how to proceed with your application.
Additional information
- The zebrafish facility at the NRC provides preclinical toxicity profiling, identification of mechanism of action, omics techniques, pharmacological testing, microscopy, high-throughput behavioural tracking, intravenous and intracerebroventricular administration. - Contact information for business inquiries: James De Pater - Telephone: 613-614-9547, Email: James.DePater@nrc-cnrc.gc.ca - Contact information for technical inquiries: Lee Ellis, Research Officer - Telephone: 902-426-2239, Email: Lee.Ellis@nrc-cnrc.gc.ca - Location of the facility: 1411 Oxford Street, Halifax, Nova Scotia B3H 3Z1 - Related links: Aquatic and Crop Resource Development Research Centre.
Grant Summary
The NRC houses an innovative zebrafish research facility that enables the development and validation of in vivo assays, methods, and disease models for industry-specific applications. The facility offers cost-effective and time-sensitive testing methods using zebrafish models, providing valuable insights into bioactivity, toxicity, and mechanism of action.
Exploring the NRC Zebrafish Research Facility Grant
The National Research Council (NRC) hosts a cutting-edge zebrafish research facility that serves as a hub for developing and validating various in vivo assays, methods, and disease models tailored for industry-specific needs. By leveraging zebrafish models at different developmental stages, including adults and early stages, the facility can effectively identify bioactivity, evaluate toxicity, and generate biologically relevant in vivo data. This innovative approach is supported by genetic research indicating a high degree of conservation between zebrafish and human genomes, making it a powerful model for understanding the effects of various test materials.
One of the key strengths of the NRC zebrafish facility is its ability to provide customized testing models and methods for a wide range of substances, such as extracts, complex mixtures, and purified compounds. This flexibility allows for collaborative research and testing projects that focus on assessing toxicological and pharmacological activities in areas like natural health products and human health therapeutics. Moreover, the facility's cost-effectiveness, with testing costs ranging from 0.1 to 1.0 percent of traditional rodent models, makes it an attractive option for companies looking to streamline their lead prioritization and address potential obstacles early in the development process.
Working with the NRC zebrafish facility offers partners the opportunity to access tailored, cost-effective, and time-sensitive industry testing methods that can accelerate the generation of biologically relevant in vivo data. By conducting trials with a high throughput at reduced costs compared to traditional vertebrate models, companies can efficiently identify lead drug candidates and anticipate any unforeseen complications associated with the test materials. With the ability to create customized disease models through transgenesis and genome modification, the facility provides a comprehensive platform for advancing research in toxicology and pharmacology.
The facility's highlights include preclinical toxicity profiling, mechanism of action identification, omics techniques, pharmacological testing, microscopy, high-throughput behavioral tracking, and specialized administration methods like intravenous and intracerebroventricular routes. These capabilities ensure that researchers and industry partners have access to state-of-the-art tools and technologies to support their experimental needs.
In conclusion, the NRC zebrafish research facility represents a valuable resource for organizations seeking innovative and cost-effective solutions for in vivo testing and disease modeling. By harnessing the unique characteristics of the zebrafish model and offering a range of specialized services, the facility plays a pivotal role in advancing research in areas such as toxicology, pharmacology, and drug discovery.
