NRC — Preclinical in vivo facility

Who is eligible?

Eligible expenses

The NRC's grant supports projects aimed at advancing the evaluation and development of biologics and vaccines, leveraging extensive expertise and state-of-the-art facilities. Eligible projects span various activities crucial for the preclinical safety and efficacy assessment of therapeutic interventions.

• Validation of therapeutic targets and biomarkers for various diseases including cancer, infectious, inflammatory, and CNS diseases.
• Evaluation of biomarker/target expression, pharmacokinetics, and pharmacodynamics.
• Studies on vaccine uptake, distribution, and immune response validation.
• Efficacy studies in challenge models for both infectious disease and cancer vaccines.
• Development of animal models for preclinical studies.
• Creation of novel molecular imaging tools and methodologies for small animal imaging.
• Comprehensive imaging support using advanced optical and hyperspectral systems.

Eligible geographic areas

The funding information provided does not specify eligible geographical areas for companies applying for this grant. Therefore, the eligible locations cannot be determined from the given context.

There are evaluation and selection criteria for this grant. The criteria include:

• Validation of therapeutic targets and biomarkers for specific diseases
• Evaluation of pharmacokinetics, pharmacodynamics, and brain penetration of biologics
• Assessment of vaccine uptake, distribution, and immune response induction
• Efficacy studies in challenge models for infectious disease and cancer vaccines
• Development of novel molecular imaging tools and methodologies

- The NRC's preclinical in vivo facility provides expertise in cancer, infectious, inflammatory, and CNS diseases. - Evaluation includes biomarker/target expression, pharmacokinetics, pharmacodynamics, and brain penetration of biologics in various models. - Vaccine studies cover uptake, distribution, immune response induction, and efficacy in challenge models. - Animal model development and customization are available. - The facility offers state-of-the-art imaging tools, from optical to microCT and mass spectrometry. - Experienced in working with various animal species and specialized surgical procedures. - Behavioral testing capabilities include maze tests. - Access to a range of imaging systems and microscopy platforms for detailed analysis. - The team at the facility has over 25 years of experience and can help with IND applications. - Good Animal Practice certification and ethical review processes are in place. - The location of the facility is in Ottawa, Ontario, Canada.