Grand Challenges Canada is a prominent organization dedicated to innovating and addressing global health and development issues. Established in 2010, it is funded primarily by the Government of Canada and collaborates with various international partners. The organization is committed to supporting innovative solutions that have the potential to improve and save lives in low- and middle-income countries. One of the core principles of Grand Challenges Canada is its support for high-impact innovations through grants and funding opportunities. These are aimed at businesses, non-profits, and institutions working to develop solutions in global health and other areas such as mental health, maternal and child health, and sexual and reproductive health and rights. The organization's funding model typically focuses on catalyzing bold ideas at early stages and scaling proven solutions to amplify their impact. Grand Challenges Canada is known for its signature programs, including Saving Lives at Birth, Saving Brains, and Global Mental Health. Each program targets specific challenges and seeks pioneering ideas that can address these issues effectively. For instance, Saving Lives at Birth is an initiative that supports innovations to prevent infant and maternal deaths during childbirth. Saving Brains focuses on early childhood development, recognizing the importance of cognitive and emotional development in the first years of life. The Global Mental Health program addresses mental health challenges in low-resource settings, encouraging solutions that integrate mental health care into existing systems. One of the unique aspects of Grand Challenges Canada is its integrated approach to funding. They utilize two main funding streams: seed funding for early-stage innovations, and transition-to-scale funding for scaling up interventions that have demonstrated success. Seed funding is crucial for innovators at the initial stages, providing them with the necessary resources to develop and pilot their ideas. This funding often attracts early-stage businesses, research institutions, and non-profits with promising concepts. Transition-to-scale funding, on the other hand, is intended for projects that have shown effectiveness and are ready to be broadened to reach larger populations. This stage of funding is vital as it provides the resources necessary for distribution and wider implementation, ensuring that successful interventions can benefit more people and create sustained impact. Grand Challenges Canada is also active in capacity building and partnership development. By collaborating with other global leaders, local governments, and communities, the organization ensures that funded projects are not only innovative but also culturally appropriate and sustainable. Partnerships with local organizations are crucial for the implementation and acceptance of innovations, fostering an environment conducive to lasting change. In addition to funding, Grand Challenges Canada offers support in the form of mentoring, networking opportunities, and access to global platforms, which can be transformative for innovators and their projects. This holistic support framework helps ensure that innovative solutions are not only funded but are also given the best chances for success through strategic advice and guidance. Grand Challenges Canada remains a key player in the global innovation landscape by amplifying the reach and impact of creative solutions to some of the most pressing health and development challenges. Its commitment to innovation, partnership, and sustainable impact resonates through its extensive support for businesses and non-profits striving to make a difference.