How much funding can be received?

There is no informations about how much funding can be received.

What is the deadline to apply?

The deadline to apply is not specified.

Who are the financial supporters of the NRC — Cell Culture Pilot Plant?

NRC — Cell Culture Pilot Plant is funded by National Research Council Canada (NRC), Government of Canada

What are NRC — Cell Culture Pilot Plant's eligibility criterias?

The applicant must be involved in biotechnology, focusing on the production and purification of biologics or vaccines. The project should require access to advanced bioprocessing services and equipment for cell culture scale-up. The applicant must seek to optimize or mimic existing cGMP-compatible bioprocesses for potential transition to a contract manufacturing organization.

NRC — Cell Culture Pilot Plant

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QC, Canada

Biologics and vaccine production facility in Montreal

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grant_single|openingDate November 14, 2019

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Researchers And Facilities

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Manufacturing
Professional, scientific and technical services
Health care and social assistance

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National Research Council Canada (NRC)
Government of Canada

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Fee-for-service cell culture pilot plant offering development and scale-up for the production of biologics and vaccines using CHO, HEK 293 and other animal cell expression systems.

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This grant facilitates the development and optimization of bioprocesses for biologics and vaccines, focusing on leveraging advanced cell culture systems. Eligible projects aim to enhance scale-up, purification, and production capabilities.

Development and scale-up of batch, fed-batch, or perfusion cell culture processes up to 500 L scale for biologics production.
Scale-up of viral production and purification processes.
Scale-up of transient transfection processes.
Development of cell culture media and feeding strategies for process optimization.
In-process assay development to ensure robust production outcomes.
Customized, hands-on training on bioreactor operation up to 500 L scale for technology transfer and workforce development.

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$ 220,000

Development of custom cell culture media for the optimization of an antibody production process

$ 200,000

Conducting hands-on training for bioreactor operation up to 500 L scale

$ 250,000

Developing a 500 L scale bioreactor process for vaccine production using CHO cells

$ 270,000

Development and scale-up of a perfusion cell culture process for biologics production

$ 280,000

Optimization of transient transfection processes for the production of therapeutic proteins

$ 300,000

Scale-up of viral production processes for gene therapy applications

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Eligibility criteria:

Canadian biotechnology companies
Businesses involved in pilot-scale production and purification of biologics, viral vectors, and vaccines

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This program is ideal for biotechnology companies involved in the pilot-scale production and purification of recombinant proteins, viral vectors, and vaccines. It is particularly suited for those aiming to optimize cGMP-compatible bioprocesses and work towards a robust Canadian biomanufacturing sector. The program supports the scale-up process using advanced bioprocessing services and equipment.

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The grant supports projects focused on advancing bioprocessing services and equipment for the production of biologics and vaccines. It emphasizes process development and scale-up for various cell culture systems and optimization strategies.

Development and scale-up of batch, fed-batch, or perfusion cell culture processes up to 500 L scale for biologics production.
Scale-up of viral production and purification processes.
Scale-up of transient transfection processes.
Development of cell culture media and feeding strategies for process optimization.
In-process assay development.
Customized, hands-on training on bioreactor operation up to 500 L scale.

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This grant is aimed at fostering the Canadian biomanufacturing sector, suggesting a focus on companies within Canada. The explicit geographical eligibility details are not provided in the available text.

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Grant applications will be assessed based on key criteria including scientific excellence, feasibility, impact, and alignment with the objectives of the Human Health Therapeutics Research Centre.

Scientific excellence
Feasibility of the proposed project
Potential impact of the project
Alignment with the objectives of the Human Health Therapeutics Research Centre

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Here are the steps to submit an application for this grant:

Step 1: Contact the Research Centre
- Reach out to Martin Loignon, the Team Leader for Cell Culture Scale-Up, to express your interest in the services offered by the NRC’s Human Health Therapeutics Research Centre.
- Obtain detailed information about the application process, requirements, and any supporting documentation needed.
Step 2: Prepare Application
- Compile a comprehensive project proposal detailing your specific needs for process development and scale-up using the Centre’s services.
- Include objectives, expected outcomes, and how your project aligns with the NRC’s capabilities in biologics and vaccine production.
- Gather any necessary supporting documents like technical specifications and financial plans.
Step 3: Submit Application
- Follow the instructions provided by the contact at the Research Centre to submit your proposal and supporting documents.
- Ensure all documents are complete and submitted before any communicated deadline.
Step 4: Verification
- Wait for a confirmation from the NRC acknowledging receipt of your application.
- Ensure your contact details are correct for any follow-up questions or requests for additional information.

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Here are additional relevant details for this grant:

The NRC’s Human Health Therapeutics Research Centre offers specific expertise in developing high-performance liquid chromatography (HPLC) and cell-based assays.
The facility enables the transition from bench-scale process optimization to up to 500 L scale production.
The team provides customized, hands-on training on bioreactor operation up to a 500 L scale.
The cell culture pilot plant functions as an ideal facility for emerging technologies and facilitates transfer of optimized bioprocesses to a CMO.
The NRC owns proprietary versions of the HEK293 cell line, namely HEK293SF-3F6 and HEK293-6E.