NRC — Cell Culture Pilot Plant
grant_single|update April 3, 2025
QC, Canada
Biologics and vaccine production facility in Montreal
grant_single_labels|summary
grant_single|eligibleFinancing
- grant_single|noCondition
grant_single|deadlines
- grant_single|openingDate November 14, 2019
grant_single|financingType
Researchers And Facilities
grant_single|eligibleIndustries
- Manufacturing
- Professional, scientific and technical services
- Health care and social assistance
grant_single|grantors
- National Research Council Canada (NRC)
- Government of Canada
grant_single|status
grant_card_status|open
grant_single_labels|preview
Fee-for-service cell culture pilot plant offering development and scale-up for the production of biologics and vaccines using CHO, HEK 293 and other animal cell expression systems.
grant_single_labels|projects
This grant facilitates the development and optimization of bioprocesses for biologics and vaccines, focusing on leveraging advanced cell culture systems. Eligible projects aim to enhance scale-up, purification, and production capabilities.
- Development and scale-up of batch, fed-batch, or perfusion cell culture processes up to 500 L scale for biologics production.
- Scale-up of viral production and purification processes.
- Scale-up of transient transfection processes.
- Development of cell culture media and feeding strategies for process optimization.
- In-process assay development to ensure robust production outcomes.
- Customized, hands-on training on bioreactor operation up to 500 L scale for technology transfer and workforce development.
grant_single|admissibleProjectsExample
$ 220,000
Development of custom cell culture media for the optimization of an antibody production process
$ 200,000
Conducting hands-on training for bioreactor operation up to 500 L scale
$ 250,000
Developing a 500 L scale bioreactor process for vaccine production using CHO cells
$ 270,000
Development and scale-up of a perfusion cell culture process for biologics production
$ 280,000
Optimization of transient transfection processes for the production of therapeutic proteins
$ 300,000
Scale-up of viral production processes for gene therapy applications
grant_single_labels|admissibility
Eligibility criteria:
- Canadian biotechnology companies
- Businesses involved in pilot-scale production and purification of biologics, viral vectors, and vaccines
grant_eligibility_criteria|who_can_apply
This program is ideal for biotechnology companies involved in the pilot-scale production and purification of recombinant proteins, viral vectors, and vaccines. It is particularly suited for those aiming to optimize cGMP-compatible bioprocesses and work towards a robust Canadian biomanufacturing sector. The program supports the scale-up process using advanced bioprocessing services and equipment.
grant_eligibility_criteria|eligible_expenses
The grant supports projects focused on advancing bioprocessing services and equipment for the production of biologics and vaccines. It emphasizes process development and scale-up for various cell culture systems and optimization strategies.
- Development and scale-up of batch, fed-batch, or perfusion cell culture processes up to 500 L scale for biologics production.
- Scale-up of viral production and purification processes.
- Scale-up of transient transfection processes.
- Development of cell culture media and feeding strategies for process optimization.
- In-process assay development.
- Customized, hands-on training on bioreactor operation up to 500 L scale.
grant_eligibility_criteria|zone
This grant is aimed at fostering the Canadian biomanufacturing sector, suggesting a focus on companies within Canada. The explicit geographical eligibility details are not provided in the available text.
grant_single_labels|criteria
Grant applications will be assessed based on key criteria including scientific excellence, feasibility, impact, and alignment with the objectives of the Human Health Therapeutics Research Centre.
- Scientific excellence
- Feasibility of the proposed project
- Potential impact of the project
- Alignment with the objectives of the Human Health Therapeutics Research Centre
grant_single_labels|apply
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grant_single_labels|otherInfo
Here are additional relevant details for this grant:
- The NRC’s Human Health Therapeutics Research Centre offers specific expertise in developing high-performance liquid chromatography (HPLC) and cell-based assays.
- The facility enables the transition from bench-scale process optimization to up to 500 L scale production.
- The team provides customized, hands-on training on bioreactor operation up to a 500 L scale.
- The cell culture pilot plant functions as an ideal facility for emerging technologies and facilitates transfer of optimized bioprocesses to a CMO.
- The NRC owns proprietary versions of the HEK293 cell line, namely HEK293SF-3F6 and HEK293-6E.
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