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NRC — Cell Culture Pilot Plant - QC - Canada

NRC — Cell Culture Pilot Plant

Last Update: April 3, 2025
QC, Canada
Biologics and vaccine production facility in Montreal

NRC — Cell Culture Pilot Plant at a glance

Eligible Funding
  • No Condition
Timeline
  • Open Date : November 14, 2019
Financing Type
Researchers And Facilities
Eligible Industries
  • Manufacturing
  • Professional, scientific and technical services
  • Health care and social assistance
Grant Providers
  • National Research Council Canada (NRC)
  • Government of Canada
Status
Open

Overview of the NRC — Cell Culture Pilot Plant program

Fee-for-service cell culture pilot plant offering development and scale-up for the production of biologics and vaccines using CHO, HEK 293 and other animal cell expression systems.

Eligible projects & activities

This grant facilitates the development and optimization of bioprocesses for biologics and vaccines, focusing on leveraging advanced cell culture systems. Eligible projects aim to enhance scale-up, purification, and production capabilities.
  • Development and scale-up of batch, fed-batch, or perfusion cell culture processes up to 500 L scale for biologics production.
  • Scale-up of viral production and purification processes.
  • Scale-up of transient transfection processes.
  • Development of cell culture media and feeding strategies for process optimization.
  • In-process assay development to ensure robust production outcomes.
  • Customized, hands-on training on bioreactor operation up to 500 L scale for technology transfer and workforce development.
Examples of admissible projects:

$ 220,000

Development of custom cell culture media for the optimization of an antibody production process

$ 200,000

Conducting hands-on training for bioreactor operation up to 500 L scale

$ 250,000

Developing a 500 L scale bioreactor process for vaccine production using CHO cells

$ 270,000

Development and scale-up of a perfusion cell culture process for biologics production

$ 280,000

Optimization of transient transfection processes for the production of therapeutic proteins

$ 300,000

Scale-up of viral production processes for gene therapy applications

Eligibility criteria of the NRC — Cell Culture Pilot Plant program

Eligibility criteria:
  • Canadian biotechnology companies
  • Businesses involved in pilot-scale production and purification of biologics, viral vectors, and vaccines

Who is eligible?

This program is ideal for biotechnology companies involved in the pilot-scale production and purification of recombinant proteins, viral vectors, and vaccines. It is particularly suited for those aiming to optimize cGMP-compatible bioprocesses and work towards a robust Canadian biomanufacturing sector. The program supports the scale-up process using advanced bioprocessing services and equipment.

Eligible expenses

The grant supports projects focused on advancing bioprocessing services and equipment for the production of biologics and vaccines. It emphasizes process development and scale-up for various cell culture systems and optimization strategies.
  • Development and scale-up of batch, fed-batch, or perfusion cell culture processes up to 500 L scale for biologics production.
  • Scale-up of viral production and purification processes.
  • Scale-up of transient transfection processes.
  • Development of cell culture media and feeding strategies for process optimization.
  • In-process assay development.
  • Customized, hands-on training on bioreactor operation up to 500 L scale.

Eligible geographic areas

This grant is aimed at fostering the Canadian biomanufacturing sector, suggesting a focus on companies within Canada. The explicit geographical eligibility details are not provided in the available text.

Eligibility criteria of the NRC — Cell Culture Pilot Plant program

Grant applications will be assessed based on key criteria including scientific excellence, feasibility, impact, and alignment with the objectives of the Human Health Therapeutics Research Centre.
  • Scientific excellence
  • Feasibility of the proposed project
  • Potential impact of the project
  • Alignment with the objectives of the Human Health Therapeutics Research Centre

How to apply to the NRC — Cell Culture Pilot Plant program

1
Of course! Please provide the French text you'd like me to translate into English.
  • Understand the eligibility criteria for the grant
  • Consult the specific requirements related to research and development projects
  • Check if your company meets the funding criteria
2
Of course! Please provide the French text you would like me to translate into English.
  • Prepare the required documentation for the grant application
  • Gather information on the project, objectives, proposed budgets, etc.
  • Check the submission deadlines for applications and the procedures to follow
3
Of course! Please provide the French text you would like me to translate into English.
  • Write the project proposal, highlighting the strengths and innovation
  • Present a detailed work plan and a marketing strategy if necessary
  • Adjust the proposal according to the specific expectations of the grant
4
Of course! Please provide the French text you'd like translated into English.
  • Submit the grant application within the designated deadlines
  • Ensure that all required documents are included and complete
  • Be prepared to answer any questions from the evaluators if needed

Additional information

Here are additional relevant details for this grant:
  • The NRC’s Human Health Therapeutics Research Centre offers specific expertise in developing high-performance liquid chromatography (HPLC) and cell-based assays.
  • The facility enables the transition from bench-scale process optimization to up to 500 L scale production.
  • The team provides customized, hands-on training on bioreactor operation up to a 500 L scale.
  • The cell culture pilot plant functions as an ideal facility for emerging technologies and facilitates transfer of optimized bioprocesses to a CMO.
  • The NRC owns proprietary versions of the HEK293 cell line, namely HEK293SF-3F6 and HEK293-6E.

Documents and links

NRC — Cell Culture Pilot Plant

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