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The University of Ottawa Heart Institute (UOHI) is Canada’s largest and foremost cardiovascular health center dedicated to providing cutting-edge patient care, advancing cardiovascular health through research, and educating future healthcare professionals. Founded in 1976 by Dr. Wilbert Keon, the institute has become a leading light in cardiovascular medicine, attracting patients from across Canada and beyond. It is an independent hospital on the campus of the Ottawa Hospital and serves the people of eastern Ontario and western Quebec. Central to the Heart Institute’s success is its commitment to innovative research that spans basic science, clinical trials, and population health. This comprehensive research approach is made possible through a variety of grants and funding opportunities. Researchers at UOHI are supported by funding from federal and provincial governments, non-profit organizations, and private partners. This financial backing allows the institute to conduct world-renowned research on cardiovascular diseases, including heart failure, arrhythmias, coronary artery disease, valvular heart disease, and the development of new medical devices and technologies. The Heart Institute collaborates closely with various industries, businesses, and non-profit organizations to translate research findings into practical applications that improve patient care and outcomes. While primarily a research and clinical institution, the Heart Institute offers several opportunities for businesses and non-profit organizations to engage in collaborative projects. These partnerships can potentially leverage UOHI’s access to federal and provincial grants aimed at translational research and innovation in healthcare. For businesses, particularly those in the medical technology and pharmaceutical sectors, the Heart Institute represents a pragmatic partner in the advancement and commercialization of medical technologies. Collaborations often take the form of joint ventures, cooperative research and development agreements, or clinical trials. These collaborative efforts are designed to bolster the development of new treatments and devices, ensuring that they make it to the market efficiently while maintaining high safety and efficacy standards. Non-profit organizations can also find opportunities for partnership. The Heart Institute is active in community engagement and education, often collaborating with non-profits to deliver public health campaigns and programs focused on preventive care and lifestyle modifications to combat heart disease. Such collaborations can draw on funding from health promotion grants and sponsorships. Funding for these initiatives comes from a combination of sources. National entities such as the Canadian Institutes of Health Research (CIHR), Heart and Stroke Foundation of Canada, and the Natural Sciences and Engineering Research Council of Canada (NSERC) provide substantial research grants. The Heart Institute is also successful in obtaining funding from private foundations and industry sponsors, who are keen to support pioneering cardiovascular research and technologies. In summary, while the core mission of the University of Ottawa Heart Institute is centered on patient care, education, and research, its openness to collaboration forms a vital part of its operations. Through strategic partnerships and diverse funding sources, the Heart Institute not only stays at the forefront of cardiovascular medicine but also extends its influence and impact by fostering innovation and improving public health. Whether through joint research initiatives or public health projects, businesses and non-profit organizations can engage with UOHI to explore opportunities that offer mutual benefits and further the mission of improving heart health worldwide.